The Binding Of Isaac: Unlock All Characters

The Binding of Isaac is a two-dimensional sprite-based top-down dungeon crawler game in which the player controls Isaac or other unlockable characters as they explore Isaac’s underground dungeons.

The characters differ in terms of speed, health, damage dealt, and other characteristics. The player must combat enemies in each area on each floor of the basement dungeon before moving on to the next. We’ll show you how to unlock all of the characters in this article. Enjoy!

The Binding Of Isaac

The Binding of Isaac is unquestionably one of the most enjoyable, exciting, and in-depth Indie releases. What began as a simple game quickly grew in popularity, prompting the creator to produce tons of DLC.

With the release of Repentance – the conclusion of The Binding of Isaac now is a fantastic moment to dive into the game for the first time and play through the complete adventure from beginning to end. There are numerous objects and characters to discover, some of which are quite tough to obtain.

Screengrab Courtesy of 2 Left Thumbs via YouTube


How To Obtain


  • Azazel can be unlocked by making three bargains with the Devil in a single run.
  • A Devil Room must spawn at least once in a run, and you must have enough heart containers to sacrifice in order to accept the offers.
  • HP: 3 x Full Black Hearts
  • Damage: 5.5
  • Range: 4.5
  • Speed: 1.25
  1. You must battle Mega Satan in order to unlock Apollyon.
    • Mega Satan is located on the same floor as The Lamb but is hidden behind the giant locked golden door in the floor’s starting area.
    • To open this door, you must combine two crucial components, both of which are difficult to open.
  2. First, when playing as ???, you must defeat The Lamb.
    • To be able to unlock them After that, you must obtain two Angel Rooms and beat the Angel boss inside those two. The fights are started by bombing the angel statue in the center of the room.
    • Take the two key pieces to the Dark Room or Chest, and the door will immediately unlock, allowing you to vanquish Mega Satan and unlock Apollyon.
  • HP: 2 x Full Red Hearts
  • Damage: 3.5
  • Range: 6.5
  • ​​​​​​​Speed: 1.0
  • Playing as Lazarus on Binding Of Isaac’s hard mode unlocks Bethany.
  • Without losing a life, you must run all the way to Mom’s Heart/It Lives and defeat it. This will be a difficult task for Lazarus because he was much weaker in his first life.
  • HP: 3 x Full Red Hearts
  • Damage: 3.5
  • Range: 6.5
  • ​​​​​​​Speed: 1.0
  • Unlocking Cain is another simple task, but it does need a consistent level of luck over the course of a run.
  • Cain may only be unlocked by holding 55 coins at once.
  • Because this is rare to happen organically in a run, your best bet is to try your luck at the slot machines if you come across one.
  • HP: 2 x Full Red Hearts
  • Damage: 4.2
  • Range: 4.5
  • Speed: 1.3
  • To access Eve, you must complete a task in which you must not pick up any hearts for two levels in a row, implying that you are cautious of receiving damage.
  • HP: 2 x Full Red Hearts
  • Damage: 2.62 (growing to 3.5 with 1 x Full Heart remaining).
  • Range: 6.5
  • Speed: 1.23
  • To get Eden,  you’ll need to finish The Womb, which means you’ll have to beat Mom’s Heart for the first time.
  • Defeating the final boss is required.
  • HP: Random
  • Damage: Random
  • Range: Random
  • ​​​​​​​Speed: Random
  • To unlock Judas in Binding Of Isaac, you must defeat Satan. Sheol, the secret floor, is where Satan can be located.
  • At the end of Womb II, a Devil Door will appear, containing the trapdoor that leads to Sheol, sometimes after fighting Mom’s Heart, but always after beating ‘It Lives’.
  • HP: 1 x Full Red Heart
  • Damage: 4.72
  • Range: 6.5
  • Speed: 1.0
  • Samson, like Eve, is unlocked by completing a challenge in which you must not take any damage for two consecutive floors.
  • It’s one of the more difficult challenges for a character to complete, although experienced players should be able to complete it in a few tries throughout the first two floors.
  • HP: 3 x Full Red Hearts
  • Damage: 3.5
  • Range: 5.0
  • Speed: 1.1
  • Lazarus is one of the most straightforward characters to unlock, although this will take some effort.
  • At the same time, players must have 4 Soul Hearts or Black Hearts.
  • Soul Hearts aren’t hard to get by, but you must be cautious about how much damage you take because Soul Hearts are always the first to be lost.
  • HP: 3 x Full Red Hearts
  • Damage: 3.5
  • Range: 4.5
  • Speed: 1.0
Jacob & Esau
  1. To begin, you must obtain the achievement “A Secret Exit.” This is accomplished through defeating repentance bosses like as Baby Plum, Reap Creep, and The Pile, who are normal bosses found in Basement and Depths.
    • Once that’s done, a locked door will appear at the end of Basement, which may be opened with a key to lead you to Downpour.
    • On one of those floors, there will be a room with a white fireplace that, when touched, will change you into The Lost. This will allow you to enter the Mirrored World through a mirror, locate the Treasure Room, and obtain Knife Piece 1.
  2. After the conclusion of Downpour, a new door will appear that requires two bombs to open.
    • This will transport you to Mines. A room with a minecart on a damaged track and a boarded-up door will spawn there.
    • To fix the railway, find three yellow buttons on the floor and press them, then touch the minecart. Knife Piece 2 will be found inside the room, which when combined will form Mom’s Knife.
  3. At the end of Mines, there will be a door that will cost two hearts to open, but The Lost will be able to enter for free.
    • This is the entrance to the Mausoleum. When you reach the bottom of this floor and fight Mom, a meaty door will appear.
    • It will open if you stab it with the knife. Inside, defeat Mom’s Heart, and a room will appear, containing the Corpse entrance.
  4. Once you’ve completed Corpse, the Mother battle will begin. Be prepared for a multi-stage confrontation, and overcoming her will unlock Jacob and Esau.
  • HP: 3 x Full Red Hearts (1 x Full Red Heart, 1 x Full Soul Heart as Esau)
  • Damage: 2.75 (3.75 as Esau)
  • Range: 1.15 (0.85 as Esau)
  • ​​​​​​​Speed: 1.0
  • Unlocking them will take a lot of time and effort, and will once again revolve around the game’s Greed Mode.
  • When Ultra Greed is beaten at the end of each Greed Mode run, a donation machine similar to the one in the shop appears.
  • You can put all of their spare coins into this machine, which will gradually unlock character enhancements.
  • To unlock Keeper, you must first increase the counter on this machine to 999, then deposit another coin to reset it to zero.
  • HP: 3 x Full Coin Hearts (after conditions are met)
  • Damage: 4.2
  • Range: 6.5
  • ​​​​​​​Speed: 0.85
  • Unlocking Lilith requires beating Greed Mode whilst playing as Azazel.
  • Greed Mode is a wave-based mode where players must defeat waves of enemies on seven different floors, before defeating a unique boss, known as Ultra Greed.
  • HP: 1 x Full Red Heart, 2 x Full Black Hearts
  • Damage: 3.5
  • Range: 6.5
  • ​​​​​​​Speed: 1.0
  • To access Magdalene, you must have seven heart containers at the same time.
  • There are a lot of objects that grant more heart containers, and they’re very abundant on the early floors, so you should have no issue getting her.
  • HP: 4 x Full Red Hearts
  • Damage: 3.5
  • Range: 6.5
  • Speed: 0.85
The Forgotten
  1. The most difficult character to unlock is this one, with secrets layered on top of secrets.
    • To begin, play as any character and fight the boss on the first level in under a minute (a sound effect will play to signal success). Next, proceed to the floor’s beginning room, which should be obscured by the shadow of a shovel.
    • The Broken Shovel item will appear if you place a bomb anywhere in the room. This thing makes Mom want to stomp on you all the time, so be careful.
  2. You must reach the Depths in under 20 minutes to defeat Mom, which unlocks the Boss Rush.
    • If you beat the Boss Rush, you’ll receive the second piece of the Broken Shovel, creating Mom’s Shovel.
    • Next, discover the Grave Room on the Dark Room floor, which should have a solitary patch of soil in the center. The Forgotten will be opened if you use Mom’s Shovel while standing in the dirt.
  • HP: 2 x Full Bone Heart (1 x Full Soul Heart as Soul)
  • Damage: 3.5
  • Range: 6.5
  • ​​​​​​​Speed: 1.0 (1.3 as Soul)
The Lost
  1. To unlock The Lost, you must die in a Sacrifice Room while holding the Missing Poster item.
    • Although it appears straightforward, defeating The Lamb while playing as Isaac is required to obtain the Missing Poster.
    • The Lamb is a hidden boss that can only be accessed by beating Satan five times while carrying The Negative item.
  2. Alternatively injuring yourself on the spikes in a Sacrifice Room 12 times on the same floor would result in a 50% probability of being teleported to the floor where The Lamb awaits.
    • For every hit on the spikes after the 12th, this 50% probability is rerolled.
  • HP: No Health
  • Damage: 3.5
  • Range: 6.5
  • ​​​​​​​Speed: 1.0
  • To unlock ???, you will need some work, since you must defeat Mom’s Heart ten times, effectively completing the game 11 times.
  • HP: 3 x Full Soul Hearts
  • Damage: 3.67
  • Range: 6.5
  • Speed: 1.1
Tainted Characters
  • You must get the Red Key during a run and use it on a Hidden closet in the Home level to unlock a Tainted version of a character.
  • Doing so on a certain character will unlock the tainted form of that character, meaning you will have to do so 17 times to gather them all.
  • HP: ???
  • Damage: ???
  • Range: ???
  • ​​​​​​​Speed: ???
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